[PDF][PDF] ROS: really involved in oxygen sensing
WG Kaelin - Cell metabolism, 2005 - cell.com
WG Kaelin
Cell metabolism, 2005•cell.comThe role of reactive oxygen species (ROS) in the cellular response to cellular oxygen
sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle et
al., 2005; Guzy et al., 2005; Mansfield et al., 2005) used genetic tools to establish that ROS
produced by mitochondria are required for the normal induction of HIF (hypoxia-inducible
factor), which is a master regulator of oxygen-sensitive gene expression, by low oxygen.
sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle et
al., 2005; Guzy et al., 2005; Mansfield et al., 2005) used genetic tools to establish that ROS
produced by mitochondria are required for the normal induction of HIF (hypoxia-inducible
factor), which is a master regulator of oxygen-sensitive gene expression, by low oxygen.
The role of reactive oxygen species (ROS) in the cellular response to cellular oxygen sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle et al., 2005; Guzy et al., 2005; Mansfield et al., 2005) used genetic tools to establish that ROS produced by mitochondria are required for the normal induction of HIF (hypoxia-inducible factor), which is a master regulator of oxygen-sensitive gene expression, by low oxygen.
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