[HTML][HTML] Induction of cIAP-2 in human colon cancer cells through PKCδ/NF-κB
Q Wang, X Wang, BM Evers - Journal of Biological Chemistry, 2003 - ASBMB
Activation of protein kinase C (PKC) prevents apoptosis in certain cells; however, the
mechanisms are largely unknown. Inhibitors of apoptosis (IAP) family members, including
NAIP, cIAP-1, cIAP-2, XIAP/hILP, survivin, and BRUCE, block apoptosis by binding and
potently inhibiting caspases. Activation of NF-κB contributes to cIAP-2 induction; however,
the cellular mechanisms regulating cIAP-2 expression have not been entirely defined. In this
study, we examined the role of the PKC and NF-κB pathways in the regulation of cIAP-2 in …
mechanisms are largely unknown. Inhibitors of apoptosis (IAP) family members, including
NAIP, cIAP-1, cIAP-2, XIAP/hILP, survivin, and BRUCE, block apoptosis by binding and
potently inhibiting caspases. Activation of NF-κB contributes to cIAP-2 induction; however,
the cellular mechanisms regulating cIAP-2 expression have not been entirely defined. In this
study, we examined the role of the PKC and NF-κB pathways in the regulation of cIAP-2 in …