Forging forward with 10 burning questions on FGF23 in kidney disease
M Wolf - Journal of the American Society of Nephrology, 2010 - journals.lww.com
The discovery of fibroblast growth factor 23 (FGF23) as the causal factor in the pathogenesis
of rare forms of hypophosphatemic rickets is rapidly reshaping our understanding of
disordered mineral metabolism in chronic kidney disease (CKD). Excessive production of
FGF23 by osteocytes is an appropriate compensation to help maintain normal phosphorus
metabolism in these patients. Beginning in early CKD, progressive increases in levels of
FGF23 enhance phosphaturia on a per-nephron basis and inhibit calcitriol production …
of rare forms of hypophosphatemic rickets is rapidly reshaping our understanding of
disordered mineral metabolism in chronic kidney disease (CKD). Excessive production of
FGF23 by osteocytes is an appropriate compensation to help maintain normal phosphorus
metabolism in these patients. Beginning in early CKD, progressive increases in levels of
FGF23 enhance phosphaturia on a per-nephron basis and inhibit calcitriol production …