Animal models of psoriasis: a brief update
FO Nestle, BJ Nickoloff - Journal of the European Academy of …, 2006 - Wiley Online Library
FO Nestle, BJ Nickoloff
Journal of the European Academy of Dermatology and Venereology, 2006•Wiley Online LibraryMajor obstacles to improve our understanding of psoriasis pathogenesis and development
of new therapies are in large part due to the absence of accepted and disease‐relevant in‐
vivo models. Recent progress in the area of psoriasis disease models include the use of
humanized xenotransplantation models and genetically altered mice reflecting psoriasiform
pathology. These models provide exciting new insights into disease pathogenesis and will
hopefully enable improved pathogenesis‐based drug approaches.
of new therapies are in large part due to the absence of accepted and disease‐relevant in‐
vivo models. Recent progress in the area of psoriasis disease models include the use of
humanized xenotransplantation models and genetically altered mice reflecting psoriasiform
pathology. These models provide exciting new insights into disease pathogenesis and will
hopefully enable improved pathogenesis‐based drug approaches.
Abstract
Major obstacles to improve our understanding of psoriasis pathogenesis and development of new therapies are in large part due to the absence of accepted and disease‐relevant in‐vivo models. Recent progress in the area of psoriasis disease models include the use of humanized xenotransplantation models and genetically altered mice reflecting psoriasiform pathology. These models provide exciting new insights into disease pathogenesis and will hopefully enable improved pathogenesis‐based drug approaches.
Wiley Online Library