LRRC50, a conserved ciliary protein implicated in polycystic kidney disease
RESULTS To identify recessive mutations affecting ciliary motility, we performed a forward
genetic ENU mutagenesis screen in zebrafish. F3-generation embryos were screened, and
mutant hu255H (hereafter called lrrc50 hu255H) was isolated, based on the absence of
motile cilia in the nose and neural tube (Supplemental Figure 1).
genetic ENU mutagenesis screen in zebrafish. F3-generation embryos were screened, and
mutant hu255H (hereafter called lrrc50 hu255H) was isolated, based on the absence of
motile cilia in the nose and neural tube (Supplemental Figure 1).