A time-dependent history of mood disorders in a murine model of neuropathic pain
I Yalcin, Y Bohren, E Waltisperger, D Sage-Ciocca… - Biological …, 2011 - Elsevier
BACKGROUND: Chronic pain is clinically associated with the development of affective
disorders. However, studies in animal models of neuropathic pain are contradictory and the
relationship with mood disorders remains unclear. In this study, we aimed to characterize the
affective consequences of neuropathic pain over time and to study potential underlying
mechanisms. METHODS: Neuropathic pain was induced by inserting a polyethylene cuff
around the main branch of the right sciatic nerve in C57BL/6J mice. Anxiety-and depression …
disorders. However, studies in animal models of neuropathic pain are contradictory and the
relationship with mood disorders remains unclear. In this study, we aimed to characterize the
affective consequences of neuropathic pain over time and to study potential underlying
mechanisms. METHODS: Neuropathic pain was induced by inserting a polyethylene cuff
around the main branch of the right sciatic nerve in C57BL/6J mice. Anxiety-and depression …
