While some species and tissue types are injured by oxygen deprivation, anoxia tolerant
organisms display a protective response that has not been fully elucidated and is well-suited
to genomic and proteomic analysis. However, such methodologies have focused on
transcriptional responses, prolonged anoxia, or have used cultured cells or isolated tissues.
In this study of intact zebrafish embryos, a species capable of> 24 h survival in anoxia, we
have utilized 2D difference in gel electrophoresis to identify changes in the proteomic profile …