Declining estrogen receptor-β expression defines malignant progression of human breast neoplasia
AM Shaaban, PA O'Neill, MPA Davies… - The American journal …, 2003 - journals.lww.com
It has been shown that the risk of breast cancer developing in certain morphologically
identifiable benign breast lesions correlates with expression of estrogen receptor alpha (ER-
α). Although ER-α and ER-β genes share a large degree of homology, it is generally thought
that their distribution and functions are substantially different in many tissues. Recent
development of reliable antibodies to ER-β has provided this first opportunity to test the
hypothesis that the likelihood of malignant transformation in morphologically benign breast …
identifiable benign breast lesions correlates with expression of estrogen receptor alpha (ER-
α). Although ER-α and ER-β genes share a large degree of homology, it is generally thought
that their distribution and functions are substantially different in many tissues. Recent
development of reliable antibodies to ER-β has provided this first opportunity to test the
hypothesis that the likelihood of malignant transformation in morphologically benign breast …
