[HTML][HTML] Candidacidal activity of salivary histatins: identification of a histatin 5-binding protein on Candida albicans
M Edgerton, SE Koshlukova, TE Lo, BG Chrzan… - Journal of Biological …, 1998 - ASBMB
Candida albicans is the predominant species of yeast isolated from patients with oral
candidiasis, which is frequently a symptom of human immunodeficiency virus infection and
is a criterion for staging and progression of AIDS. Salivary histatins (Hsts) are potent in vitro
antifungal agents and have great promise as therapeutic agents in humans with oral
candidiasis. The molecular mechanisms by which Hsts kill yeast cells are not known. We
report here, that unlike other antimicrobial proteins, Hsts do not display lytic activities to lipid …
candidiasis, which is frequently a symptom of human immunodeficiency virus infection and
is a criterion for staging and progression of AIDS. Salivary histatins (Hsts) are potent in vitro
antifungal agents and have great promise as therapeutic agents in humans with oral
candidiasis. The molecular mechanisms by which Hsts kill yeast cells are not known. We
report here, that unlike other antimicrobial proteins, Hsts do not display lytic activities to lipid …