[HTML][HTML] Viperin, a key player in the antiviral response
S Mattijssen, GJM Pruijn - Microbes and infection, 2012 - Elsevier
Viperin is an antiviral protein that is induced by different viruses, type I interferon, poly (I: C)
and lipopolysaccharide, which is localized to the endoplasmic reticulum and lipid droplets.
Recently, our knowledge on the mechanism by which viperin inhibits viral replication has
strongly increased. Interestingly, it also became clear that viperin can be used by viruses to
increase their infectivity. Here, our current knowledge on the induction of viperin and its
effect on virus replication will be reviewed.
and lipopolysaccharide, which is localized to the endoplasmic reticulum and lipid droplets.
Recently, our knowledge on the mechanism by which viperin inhibits viral replication has
strongly increased. Interestingly, it also became clear that viperin can be used by viruses to
increase their infectivity. Here, our current knowledge on the induction of viperin and its
effect on virus replication will be reviewed.