Platelet-and megakaryocyte-derived microparticles
R Flaumenhaft, ATA Mairuhu… - Seminars in thrombosis …, 2010 - thieme-connect.com
R Flaumenhaft, ATA Mairuhu, JE Italiano
Seminars in thrombosis and hemostasis, 2010•thieme-connect.comPlatelet microparticles are the most abundant cell-derived microparticle subtype in the
circulation. Yet the mechanism by which platelet microparticles are formed is poorly defined.
This review highlights the concept of the generation of microparticles from platelets and their
precursor cells, megakaryocytes. Special emphasis is placed on the mechanisms of
microparticle formation and novel functions for microparticles in normal physiology and
disease states.
circulation. Yet the mechanism by which platelet microparticles are formed is poorly defined.
This review highlights the concept of the generation of microparticles from platelets and their
precursor cells, megakaryocytes. Special emphasis is placed on the mechanisms of
microparticle formation and novel functions for microparticles in normal physiology and
disease states.
Abstract
Platelet microparticles are the most abundant cell-derived microparticle subtype in the circulation. Yet the mechanism by which platelet microparticles are formed is poorly defined. This review highlights the concept of the generation of microparticles from platelets and their precursor cells, megakaryocytes. Special emphasis is placed on the mechanisms of microparticle formation and novel functions for microparticles in normal physiology and disease states.
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