Defective trafficking of rhodopsin and its role in retinal degenerations
TJ Hollingsworth, AK Gross - International review of cell and molecular …, 2012 - Elsevier
Retinitis pigmentosa is a retinal degeneration transmitted by varied modes of inheritance
and affects approximately 1 in 4000 individuals. The photoreceptors of the outer retina, as
well as the retinal pigmented epithelium which supports the outer retina metabolically and
structurally, are the retinal regions most affected by the disorder. In several forms of retinitis
pigmentosa, the mislocalization of the rod photoreceptor protein rhodopsin is thought to be a
contributing factor underlying the pathophysiology seen in patients. The mutations causing …
and affects approximately 1 in 4000 individuals. The photoreceptors of the outer retina, as
well as the retinal pigmented epithelium which supports the outer retina metabolically and
structurally, are the retinal regions most affected by the disorder. In several forms of retinitis
pigmentosa, the mislocalization of the rod photoreceptor protein rhodopsin is thought to be a
contributing factor underlying the pathophysiology seen in patients. The mutations causing …