[HTML][HTML] Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice
Y Liang, D Fotiadis, T Maeda, A Maeda… - Journal of Biological …, 2004 - ASBMB
Rhodopsin (Rho) resides within internal membrane structures called disc membranes that
are found in the rod outer segments (ROS) of photoreceptors in the retina. Rho expression is
essential for formation of ROS, which are absent in knockout Rho-/-mice. ROS of mice
heterozygous for the Rho gene deletion (Rho+/-) may have a lower Rho density than wild
type (WT) membranes, or the ROS structure may be reduced in size due to lower Rho
expression. Here, we present evidence that the smaller volume of ROS from heterozygous …
are found in the rod outer segments (ROS) of photoreceptors in the retina. Rho expression is
essential for formation of ROS, which are absent in knockout Rho-/-mice. ROS of mice
heterozygous for the Rho gene deletion (Rho+/-) may have a lower Rho density than wild
type (WT) membranes, or the ROS structure may be reduced in size due to lower Rho
expression. Here, we present evidence that the smaller volume of ROS from heterozygous …