[HTML][HTML] Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina
Q Zhu, W Sun, K Okano, Y Chen, N Zhang… - Journal of Biological …, 2011 - ASBMB
MicroRNA-183 (miR-183), miR-96, and miR-182 comprising the miR-183/96/182 cluster are
highly expressed in photoreceptor cells. Although in vitro data have indicated an important
role for this cluster in the retina, details of its in vivo biological activity are still unknown. To
observe the impact of the miR-183/96/182 cluster on retinal maintenance and light
adaptation, we generated a sponge transgenic mouse model that disrupted the activities of
the three-component microRNAs simultaneously and selectively in the retina. Although our …
highly expressed in photoreceptor cells. Although in vitro data have indicated an important
role for this cluster in the retina, details of its in vivo biological activity are still unknown. To
observe the impact of the miR-183/96/182 cluster on retinal maintenance and light
adaptation, we generated a sponge transgenic mouse model that disrupted the activities of
the three-component microRNAs simultaneously and selectively in the retina. Although our …