Prestin and the cholinergic receptor of hair cells: positively-selected proteins in mammals

AB Elgoyhen, LF Franchini - Hearing research, 2011 - Elsevier
The hair cells of the vertebrate inner ear posses active mechanical processes to amplify their
inputs. The stereocilia bundle of various vertebrate animals can produce active movements.
Though standard stereocilia-based mechanisms to promote amplification persist in
mammals, an additional radically different mechanism evolved: the so-called somatic
electromotility which refers to the elongation/contraction of the outer hair cells'(OHC)
cylindrical cell body in response to membrane voltage changes. Somatic electromotility in …