[HTML][HTML] Wnt-5a-CKIα signaling promotes β-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells
C Medrek, G Landberg, T Andersson… - Journal of biological …, 2009 - ASBMB
Wnt-5a is a non-transforming Wnt protein that is implicated in cell polarity, adhesion, and
motility. We have previously shown that low expression of Wnt-5a is a predictor of shorter
disease-free survival in human breast cancer. Here, we investigated whether β-catenin/E-
cadherin-mediated cell-cell adhesion was affected by loss of Wnt-5a in breast carcinomas,
thereby promoting a metastatic behavior of the tumor. We show that Wnt-5a stimulation of
human breast epithelial cells leads to an increased Ca 2+-dependent cell-cell adhesion …
motility. We have previously shown that low expression of Wnt-5a is a predictor of shorter
disease-free survival in human breast cancer. Here, we investigated whether β-catenin/E-
cadherin-mediated cell-cell adhesion was affected by loss of Wnt-5a in breast carcinomas,
thereby promoting a metastatic behavior of the tumor. We show that Wnt-5a stimulation of
human breast epithelial cells leads to an increased Ca 2+-dependent cell-cell adhesion …
