Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1
J Xu, N Xiao, J Xia - Nature neuroscience, 2010 - nature.com
J Xu, N Xiao, J Xia
Nature neuroscience, 2010•nature.comIn cultured rat hippocampal neurons, we found that thrombospondin 1 (TSP1) increased the
speed of synapse formation in young neurons, but not the final density of synapses in
mature neurons. TSP1 interacted with neuroligin 1 (NL1) and application of the NL1
extracellular domain blocked TSP1-induced synaptogenesis. Furthermore, knocking down
endogenous NL1 inhibited TSP1's effect. Our results indicate that TSP1 accelerates the
speed of synaptogenesis through NL1 in hippocampal neurons.
speed of synapse formation in young neurons, but not the final density of synapses in
mature neurons. TSP1 interacted with neuroligin 1 (NL1) and application of the NL1
extracellular domain blocked TSP1-induced synaptogenesis. Furthermore, knocking down
endogenous NL1 inhibited TSP1's effect. Our results indicate that TSP1 accelerates the
speed of synaptogenesis through NL1 in hippocampal neurons.
Abstract
In cultured rat hippocampal neurons, we found that thrombospondin 1 (TSP1) increased the speed of synapse formation in young neurons, but not the final density of synapses in mature neurons. TSP1 interacted with neuroligin 1 (NL1) and application of the NL1 extracellular domain blocked TSP1-induced synaptogenesis. Furthermore, knocking down endogenous NL1 inhibited TSP1's effect. Our results indicate that TSP1 accelerates the speed of synaptogenesis through NL1 in hippocampal neurons.
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