Association between urinary neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery
X Wan, CC Cao, Y Chen, YL Xiao, WF Wu… - Zhonghua yi xue za …, 2008 - europepmc.org
X Wan, CC Cao, Y Chen, YL Xiao, WF Wu, X Chen, XW Mu
Zhonghua yi xue za zhi, 2008•europepmc.orgObjective To test the hypothesis that Neutrophil gelatinase-associated lipocalin (NGAL) is an
early biomarker for acute kidney injury (AKI) in patients after cardiac surgery. Methods 33
cases undergoing cardiac surgery were divided into AKI group and Non-AKI group
according to the AKI criteria. The concentration of urine NGAL at different time points were
measured. Results (1) Nine of 33 cases (27%) developed postoperative AKI, but diagnosis
with serum creatinine was only 12-48 hours after cardiac surgery.(2) Urinary concentrations …
early biomarker for acute kidney injury (AKI) in patients after cardiac surgery. Methods 33
cases undergoing cardiac surgery were divided into AKI group and Non-AKI group
according to the AKI criteria. The concentration of urine NGAL at different time points were
measured. Results (1) Nine of 33 cases (27%) developed postoperative AKI, but diagnosis
with serum creatinine was only 12-48 hours after cardiac surgery.(2) Urinary concentrations …
Objective
To test the hypothesis that Neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for acute kidney injury (AKI) in patients after cardiac surgery.
Methods
33 cases undergoing cardiac surgery were divided into AKI group and Non-AKI group according to the AKI criteria. The concentration of urine NGAL at different time points were measured.
Results
(1) Nine of 33 cases (27%) developed postoperative AKI, but diagnosis with serum creatinine was only 12-48 hours after cardiac surgery.(2) Urinary concentrations of NGAL at 2 h after cardiac surgery in patients who did not developed AKI were significantly higher compared with those of preoperative (P< 0.001). Urinary concentrations of NGAL at 2 h and 4 h after cardiac surgery in patients who developed AKI were significantly higher compared with those of preoperative (P< 0.001).(3) The mean urinary NGAL concentrations in patients who developed AKI were significantly higher after surgery compared with patients who did not develop AKI (P< 0.01).(4) Urinary concentrations of NGAL/Ucr at 2 h and 4 h after cardiac surgery in patients who did not developed AKI were significantly higher compared with those of preoperative (P< 0.05). Urinary concentrations of NGAL/Ucr at 2 h and 4 h after cardiac surgery in patients who developed AKI were significantly higher compared with those of preoperative (P< 0.01).(The mean urinary concentrations of NGAL/Ucr in patients who developed AKI were significantly higher after surgery compared with patients who did not develop AKI (P< 0.01).(6) For concentrations in urine of NGAL at 2 h after surgery, sensitivity was 0.7125, and specificity was 0.7307 for a cutoff value of 250 microg/L. For concentrations in urine of NGAL/Ucr at 2 h after surgery, sensitivity was 0.8127, and specificity was 0.7839 for a cutoff value of 250 microg/mmol.(7) Urinary concentrations of NGAL at 2 h after cardiac surgery was significantly associated with serum creatinine 12 h postoperative (R= 0.638, P< 0.05).
Conclusions
The incidence of AKI in patients after cardiac surgery is high, which accounted for 27%. The amount of NGAL and NGAL/Ucr in urine at 2 h after cardiac surgery were the powerful independent predictor of acute renal injury and urine concentrations of NGAL/Ucr is more sensitive.
europepmc.org