748 Circ Cardiovasc Imaging July 2014 population with echocardiography or magnetic resonance angiography (MRA) have finally established the conditions for improving our knowledge of the denominator in the risk fraction (the number of cases of SCD divided by the number of persons with CAAs in the general population rather than only in autopsy series). 15, 19–22 Definitive data about CAA-associated mortality are still lacking, because of a lack of studies based on defined and controlled populations. 13 This report attempts to clarify this matter by presenting an overview of more recent and precise approaches to CAA screening, pathophysiology, and clinical evaluation.