[HTML][HTML] Farnesoid X receptor responds to bile acids and represses cholesterol 7α-hydroxylase gene (CYP7A1) transcription
JYL Chiang, R Kimmel, C Weinberger… - Journal of Biological …, 2000 - ASBMB
Cholesterol 7α-hydroxylase gene (CYP7A1) transcription is repressed by bile acids. The
goal of this study is to elucidate the mechanism of CYP7A1transcription by bile acid-
activated farnesoid X receptor (FXR) in its native promoter and cellular context and to
identify FXR response elements in the gene. In Chinese hamster ovary cells transfected with
retinoid X receptor α (RXRα)/FXR, only chenodeoxycholic acid (CDCA) and deoxycholic
acid (DCA) were able to stimulate a heterologous promoter/reporter containing an ecdysone …
goal of this study is to elucidate the mechanism of CYP7A1transcription by bile acid-
activated farnesoid X receptor (FXR) in its native promoter and cellular context and to
identify FXR response elements in the gene. In Chinese hamster ovary cells transfected with
retinoid X receptor α (RXRα)/FXR, only chenodeoxycholic acid (CDCA) and deoxycholic
acid (DCA) were able to stimulate a heterologous promoter/reporter containing an ecdysone …