[HTML][HTML] Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor
T Nishimaki-Mogami, M Une, T Fujino, Y Sato… - Journal of lipid …, 2004 - ASBMB
Bile acid synthesis from cholesterol is tightly regulated via a feedback mechanism mediated
by the farnesoid X receptor (FXR), a nuclear receptor activated by bile acids. Synthesis via
the classic pathway is initiated by a series of cholesterol ring modifications and followed by
the side chain cleavage. Several intermediates accumulate or are excreted as end products
of the pathway in diseases involving defective bile acid biosynthesis. In this study, we
investigated the ability of these intermediates to activate human FXR. In a cell-based …
by the farnesoid X receptor (FXR), a nuclear receptor activated by bile acids. Synthesis via
the classic pathway is initiated by a series of cholesterol ring modifications and followed by
the side chain cleavage. Several intermediates accumulate or are excreted as end products
of the pathway in diseases involving defective bile acid biosynthesis. In this study, we
investigated the ability of these intermediates to activate human FXR. In a cell-based …