[HTML][HTML] Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers
The side chain oxidized oxysterol 24S-hydroxycholesterol (24-OH-chol) is formed almost
exclusively in the brain, and there is a continuous passage of this oxysterol through the
circulation to the liver. 27-Hydroxycholesterol (27-OH-chol) is produced in most organs and
is also taken up by the liver. The 27-OH-chol-24-OH-chol ratio is about 0.1 in the brain and
about 2 in the circulation. This ratio was found to be about 0.4 in cerebrospinal fluid (CSF) of
asymptomatic patients, consistent with a major contribution from the circulation in the case of …
exclusively in the brain, and there is a continuous passage of this oxysterol through the
circulation to the liver. 27-Hydroxycholesterol (27-OH-chol) is produced in most organs and
is also taken up by the liver. The 27-OH-chol-24-OH-chol ratio is about 0.1 in the brain and
about 2 in the circulation. This ratio was found to be about 0.4 in cerebrospinal fluid (CSF) of
asymptomatic patients, consistent with a major contribution from the circulation in the case of …