[HTML][HTML] Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation
M Shafaati, A Marutle, H Pettersson… - Journal of lipid …, 2011 - ASBMB
There is a significant flux of the neurotoxic oxysterol 27-hydroxycholesterol (27OHC) from
the circulation across the blood-brain barrier. Because there is a correlation between
27OHC and cholesterol in the circulation and lipoprotein-bound cholesterol does not pass
the blood-brain barrier, we have suggested that 27OHC may mediate the effects of
hypercholesterolemia on the brain. We previously demonstrated a modest accumulation of
27OHC in brains of patients with sporadic Alzheimer's disease (AD), consistent with a role of …
the circulation across the blood-brain barrier. Because there is a correlation between
27OHC and cholesterol in the circulation and lipoprotein-bound cholesterol does not pass
the blood-brain barrier, we have suggested that 27OHC may mediate the effects of
hypercholesterolemia on the brain. We previously demonstrated a modest accumulation of
27OHC in brains of patients with sporadic Alzheimer's disease (AD), consistent with a role of …