[HTML][HTML] Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol …
K Rose, A Allan, S Gauldie, G Stapleton… - Journal of Biological …, 2001 - ASBMB
The major adrenal steroid dehydroepiandrosterone (DHEA) enhances memory and immune
function but has no known dedicated receptor; local metabolism may govern its activity. We
described a cytochrome P450 expressed in brain and other tissues, CYP7B, that catalyzes
the 7α-hydroxylation of oxysterols and 3β-hydroxysteroids including DHEA. We report here
that CYP7B mRNA and 7α-hydroxylation activity are widespread in rat tissues. However,
steroids related to DHEA are reported to be modified at positions other than 7α, exemplified …
function but has no known dedicated receptor; local metabolism may govern its activity. We
described a cytochrome P450 expressed in brain and other tissues, CYP7B, that catalyzes
the 7α-hydroxylation of oxysterols and 3β-hydroxysteroids including DHEA. We report here
that CYP7B mRNA and 7α-hydroxylation activity are widespread in rat tissues. However,
steroids related to DHEA are reported to be modified at positions other than 7α, exemplified …
