Cardiovascular disease is the leading cause of morbidity and mortality world-wide. The
burden of disease is also increasing as a result of the global epidemics of diabetes and
obesity. Peroxisome proliferator-activated receptor α (PPARα), a member of this nuclear
receptor family, has emerged as an important player in this scenario, with evidence
supporting a central co-ordinated role in the regulation of fatty acid oxidation, lipid and
lipoprotein metabolism and inflammatory and vascular responses, all of which would be …