[HTML][HTML] AP-1 activated by toll-like receptors regulates expression of IL-23 p19
W Liu, X Ouyang, J Yang, J Liu, Q Li, Y Gu… - Journal of biological …, 2009 - ASBMB
Interleukin (IL)-23, a new member of the IL-12 family, plays a central role in the Th17
immune response and in autoimmune diseases. It is clear that activated macrophages and
dendritic cells produce IL-23, but the molecular mechanisms whereby inflammatory signals
stimulate IL-23 expression are not fully understood. We demonstrate that induction of IL-23
p19 gene expression by LPS depends on the TLR4 and MyD88 pathways. All three MAPK
pathways (ERK, JNK, and p38) that are activated by lipopolysaccharide (LPS) stimulation …
immune response and in autoimmune diseases. It is clear that activated macrophages and
dendritic cells produce IL-23, but the molecular mechanisms whereby inflammatory signals
stimulate IL-23 expression are not fully understood. We demonstrate that induction of IL-23
p19 gene expression by LPS depends on the TLR4 and MyD88 pathways. All three MAPK
pathways (ERK, JNK, and p38) that are activated by lipopolysaccharide (LPS) stimulation …