[HTML][HTML] A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense
K Gronert, N Maheshwari, N Khan, IR Hassan… - Journal of Biological …, 2005 - ASBMB
The surface of the eye actively suppresses inflammation while maintaining a remarkable
capacity for epithelial wound repair. Our understanding of mechanisms that balance
inflammatory/reparative responses to provide effective host defense while preserving tissue
function is limited, in particular, in the cornea. Lipoxin A 4 (LXA 4) and docosahexaenoic
acid-derived neuroprotectin D1 (NPD1) are lipid autacoids formed by 12/15-lipoxygenase
(LOX) pathways that exhibit anti-inflammatory and neuroprotective properties. Here, we …
capacity for epithelial wound repair. Our understanding of mechanisms that balance
inflammatory/reparative responses to provide effective host defense while preserving tissue
function is limited, in particular, in the cornea. Lipoxin A 4 (LXA 4) and docosahexaenoic
acid-derived neuroprotectin D1 (NPD1) are lipid autacoids formed by 12/15-lipoxygenase
(LOX) pathways that exhibit anti-inflammatory and neuroprotective properties. Here, we …