[HTML][HTML] Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway
CC Leow, B Wang, J Ross, SM Chan, J Zha… - Journal of biological …, 2009 - ASBMB
Krüppel-like factor 6 (Klf6) belongs to a family of zinc finger transcription factors known to
play a role in development and tumor suppression. Although Klf6 is highly mutated in
prostate cancer, its function in prostate development is unknown. We have generated a
prostate-specific Klf6-deficient mouse model and report here a novel role for Klf6 in the
regulation of prostate branching morphogenesis. Importantly, our study reveals a novel
relationship between Klf6 and the Shh pathway. Klf6-deficiency leads to elevated levels of …
play a role in development and tumor suppression. Although Klf6 is highly mutated in
prostate cancer, its function in prostate development is unknown. We have generated a
prostate-specific Klf6-deficient mouse model and report here a novel role for Klf6 in the
regulation of prostate branching morphogenesis. Importantly, our study reveals a novel
relationship between Klf6 and the Shh pathway. Klf6-deficiency leads to elevated levels of …