Vascular signaling through G protein-coupled receptors: new concepts
M Ushio-Fukai - Current opinion in nephrology and hypertension, 2009 - journals.lww.com
M Ushio-Fukai
Current opinion in nephrology and hypertension, 2009•journals.lww.comNADPH oxidase-derived ROS and NOS-derived SNOs are now recognized as important
second messengers to regulate GPCR signaling, thereby contributing to various biological
and pathophysiological functions. Understanding the molecular mechanism of how ROS,
nitric oxide, and SNOs might modulate GPCR signaling is essential for development of novel
therapeutic approaches.
second messengers to regulate GPCR signaling, thereby contributing to various biological
and pathophysiological functions. Understanding the molecular mechanism of how ROS,
nitric oxide, and SNOs might modulate GPCR signaling is essential for development of novel
therapeutic approaches.
Summary
NADPH oxidase-derived ROS and NOS-derived SNOs are now recognized as important second messengers to regulate GPCR signaling, thereby contributing to various biological and pathophysiological functions. Understanding the molecular mechanism of how ROS, nitric oxide, and SNOs might modulate GPCR signaling is essential for development of novel therapeutic approaches.
Lippincott Williams & Wilkins