[HTML][HTML] Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques
V Cecchinato, CJ Trindade, A Laurence, JM Heraud… - Mucosal …, 2008 - Elsevier
Loss of CD4+ T cells in the gut is necessary but not sufficient to cause AIDS in animal
models, raising the possibility that a differential loss of CD4+ T-cell subtypes may be
important. We found that CD4+ T cells that produce interleukin (IL)-17, a recently identified
lineage of effector CD4+ T-helper cells, are infected by SIV mac251 in vitro and in vivo, and
are found at lower frequency at mucosal and systemic sites within a few weeks from
infection. In highly viremic animals, Th1 cells predominates over Th17 T cells and the …
models, raising the possibility that a differential loss of CD4+ T-cell subtypes may be
important. We found that CD4+ T cells that produce interleukin (IL)-17, a recently identified
lineage of effector CD4+ T-helper cells, are infected by SIV mac251 in vitro and in vivo, and
are found at lower frequency at mucosal and systemic sites within a few weeks from
infection. In highly viremic animals, Th1 cells predominates over Th17 T cells and the …