Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma
SL Corthals, M Jongen-Lavrencic, Y de Knegt… - Leukemia Research, 2010 - Elsevier
We have used copy number variation (CNV) analysis with SNP mapping arrays for miRNA-
15a and miRNA-16-1 expression analysis in patients with multiple myeloma (MM) with or
without deletion of chromosome 13q14. MiRNA-15a and miRNA-16 display a range of
expression patterns in MM patients, independent of the chromosome 13 status. These
findings suggest that genes other than miR-15a and miR-16 may explain the prognostic
significance of 13q14 deletions.
15a and miRNA-16-1 expression analysis in patients with multiple myeloma (MM) with or
without deletion of chromosome 13q14. MiRNA-15a and miRNA-16 display a range of
expression patterns in MM patients, independent of the chromosome 13 status. These
findings suggest that genes other than miR-15a and miR-16 may explain the prognostic
significance of 13q14 deletions.