Pancreatic cancer derived exosomes regulate the expression of TLR4 in dendritic cells via miR-203
M Zhou, J Chen, L Zhou, W Chen, G Ding, L Cao - Cellular immunology, 2014 - Elsevier
MicroRNAs (miRNAs) are aberrant in many human tumors which can be transferred to
immune cells by tumor-derived exosomes. Dendritic cells (DCs) play an important role in
activation of immune response. However, the effect of tumor-derived exosomes on toll-like
receptor (TLR) in DCs remains unclear. We investigated the influence of pancreatic cancer
derived exosomes on TLR4, and downstream cytokines via miR-203. Our results showed
that miR-203 expressed in panc-1 cells and exosomes, and upregulated in exosomes …
immune cells by tumor-derived exosomes. Dendritic cells (DCs) play an important role in
activation of immune response. However, the effect of tumor-derived exosomes on toll-like
receptor (TLR) in DCs remains unclear. We investigated the influence of pancreatic cancer
derived exosomes on TLR4, and downstream cytokines via miR-203. Our results showed
that miR-203 expressed in panc-1 cells and exosomes, and upregulated in exosomes …