Neural cell adhesion molecule is upregulated in nerves with prostate cancer invasion
R Li, T Wheeler, H Dai, G Ayala - Human pathology, 2003 - Elsevier
Currently postulated mechanisms of perineural invasion (PNI) include interaction between
tumor cells and nerves. Neural cell adhesion molecule (N-CAM), one of the well-known
members of the immunoglobulin super-family of adhesion molecules, was implicated in PNI
and metastasis in various types of cancer. Tissue microarray technology was used to build 2
sets of tissue array (with versus without PNI) from 50 prostate cancers (PCa). The slides
were stained immunohistochemically, and the results were evaluated semiquantitatively …
tumor cells and nerves. Neural cell adhesion molecule (N-CAM), one of the well-known
members of the immunoglobulin super-family of adhesion molecules, was implicated in PNI
and metastasis in various types of cancer. Tissue microarray technology was used to build 2
sets of tissue array (with versus without PNI) from 50 prostate cancers (PCa). The slides
were stained immunohistochemically, and the results were evaluated semiquantitatively …