[HTML][HTML] Coinduction of nitric oxide synthase, argininosuccinate synthetase, and argininosuccinate lyase in lipopolysaccharide-treated rats: RNA blot, immunoblot, and …
A Nagasaki, T Gotoh, M Takeya, Y Yu… - Journal of Biological …, 1996 - ASBMB
Nitric oxide (NO) is synthesized from arginine by nitric oxide synthase (NOS), and citrulline
which is generated can be recycled to arginine by argininosuccinate synthetase (AS) and
argininosuccinate lyase (AL). Rats were injected with bacterial lipopolysaccharide (LPS),
and expression of the inducible isoform of NOS (iNOS), AS, and AL was analyzed. In RNA
blot analysis, iNOS mRNA was undetectable before the LPS treatment but was induced by
LPS in the lung, heart, liver, and spleen, and less strongly in the skeletal muscle and testis …
which is generated can be recycled to arginine by argininosuccinate synthetase (AS) and
argininosuccinate lyase (AL). Rats were injected with bacterial lipopolysaccharide (LPS),
and expression of the inducible isoform of NOS (iNOS), AS, and AL was analyzed. In RNA
blot analysis, iNOS mRNA was undetectable before the LPS treatment but was induced by
LPS in the lung, heart, liver, and spleen, and less strongly in the skeletal muscle and testis …