[HTML][HTML] Protein-tyrosine kinase Pyk2 mediates endothelin-induced p38 MAPK activation in glomerular mesangial cells

A Sorokin, P Kozlowski, L Graves, A Philip - Journal of Biological Chemistry, 2001 - ASBMB
Endothelin-1 (ET-1), a member of a family of 21 amino acid peptides possessing
vasoconstrictor properties, is known to stimulate mesangial cell proliferation. In this study, ET-
1 (100 nm) induced a rapid activation of p21 ras in human glomerular mesangial cells
(HMC). Inhibition of Src family tyrosine kinase activation with [4-Amino-5-(4-methylphenyl)-7-
(t-butyl) pyrazolo [3, 4-d] pyrimidine] or chelation of intracellular free calcium with 1, 2-bis (2-
aminophenoxy) ethane-N, N, N′, N′-tetraacetic acid acetoxymethyl ester significantly …