Sortilin-related receptor with A-type repeats (SORLA) is a sorting receptor that impairs
processing of amyloid precursor protein (APP) to soluble (s) APP and to the amyloid β-
peptide in cultured neurons and is poorly expressed in patients with Alzheimer disease
(AD). Here, we evaluated the consequences of Sorla gene defects on brain anatomy and
function using mouse models of receptor deficiency. In line with a protective role for SORLA
in APP metabolism, lack of the receptor results in increased amyloidogenic processing of …