[HTML][HTML] Regulation of glut1 mRNA by hypoxia-inducible factor-1: interaction between H-ras and hypoxia
C Chen, N Pore, A Behrooz, F Ismail-Beigi… - Journal of Biological …, 2001 - ASBMB
Oncogenic transformation and hypoxia both induceglut1 mRNA. We studied the interaction
between theras oncogene and hypoxia in up-regulating glut1mRNA levels using Rat1
fibroblasts transformed with H-ras (Rat1-ras). Transformation with H-ras led to a substantial
increase in glut1mRNA levels under normoxic conditions and additively increasedglut1
mRNA levels in concert with hypoxia. Using a luciferase reporter construct containing 6
kilobase pairs of theglut1 promoter, we showed that this effect was mediated at the …
between theras oncogene and hypoxia in up-regulating glut1mRNA levels using Rat1
fibroblasts transformed with H-ras (Rat1-ras). Transformation with H-ras led to a substantial
increase in glut1mRNA levels under normoxic conditions and additively increasedglut1
mRNA levels in concert with hypoxia. Using a luciferase reporter construct containing 6
kilobase pairs of theglut1 promoter, we showed that this effect was mediated at the …