Altered T-cell receptor signaling in the pathogenesis of allergic disease
S Datta, JD Milner - Journal of allergy and clinical immunology, 2011 - Elsevier
Mounting evidence from animal models has demonstrated that alterations in T-cell receptor
(TCR) signaling alone can lead to dramatically skewed differentiation of naive T cells into
TH2 cells, to TH2 effector functions, and to TH2-related diseases. There is significant
potential relevance of these observations to human disease. Specifically, a number of
immunodeficiencies associated with atopic disease might have atopy as a manifestation
because of aberrant TCR signaling. It is therefore important to attempt to identify a role for …
(TCR) signaling alone can lead to dramatically skewed differentiation of naive T cells into
TH2 cells, to TH2 effector functions, and to TH2-related diseases. There is significant
potential relevance of these observations to human disease. Specifically, a number of
immunodeficiencies associated with atopic disease might have atopy as a manifestation
because of aberrant TCR signaling. It is therefore important to attempt to identify a role for …