Maternal high-fat diets cause insulin resistance through inflammatory changes in fetal adipose tissue
N Murabayashi, T Sugiyama, L Zhang… - European Journal of …, 2013 - Elsevier
OBJECTIVES: Epidemiological and animal studies have shown that maternal obesity
predisposes the offspring to obesity and the metabolic syndrome, possibly via late-onset
metabolic programming of the fetus. Little is known, however, about the metabolic effect of
maternal obesity on the fetus. This study investigated the effect of a maternal high-fat diet
(HFD) on fetal growth and glucose metabolism using a diet-induced obesity mouse model.
STUDY DESIGN: Female mice (6 weeks old; C57BL/6N) were fed either a normal chow diet …
predisposes the offspring to obesity and the metabolic syndrome, possibly via late-onset
metabolic programming of the fetus. Little is known, however, about the metabolic effect of
maternal obesity on the fetus. This study investigated the effect of a maternal high-fat diet
(HFD) on fetal growth and glucose metabolism using a diet-induced obesity mouse model.
STUDY DESIGN: Female mice (6 weeks old; C57BL/6N) were fed either a normal chow diet …