Alterations in components of the TGF-β superfamily signaling pathways in human cancer
L Levy, CS Hill - Cytokine & growth factor reviews, 2006 - Elsevier
Signaling by transforming growth factor-β (TGF-β) superfamily ligands to the nucleus is
mediated by type I and type II receptors and the intracellular signal transducers, the Smads.
Alteration of some of the components of these pathways has been observed in human
tumors. These alterations can be deletions or mutations, or downregulation of components
that act positively in the pathway, or alternatively, amplification or overexpression of
inhibitors of the pathways. The selection of these alterations during tumor progression and …
mediated by type I and type II receptors and the intracellular signal transducers, the Smads.
Alteration of some of the components of these pathways has been observed in human
tumors. These alterations can be deletions or mutations, or downregulation of components
that act positively in the pathway, or alternatively, amplification or overexpression of
inhibitors of the pathways. The selection of these alterations during tumor progression and …