[HTML][HTML] A key requirement for CD300f in innate immune responses of eosinophils in colitis

I Moshkovits, H Reichman, D Karo-Atar… - Mucosal …, 2017 - Elsevier
Eosinophils are traditionally studied in the context of type 2 immune responses. However,
recent studies highlight key innate immune functions for eosinophils especially in colonic
inflammation. Surprisingly, molecular pathways regulating innate immune activities of
eosinophil are largely unknown. We have recently shown that the CD300f is highly
expressed by colonic eosinophils. Nonetheless, the role of CD300f in governing innate
immune eosinophil activities is ill-defined. RNA sequencing of 162 pediatric Crohn's disease …