Resolution of inflammation: a new therapeutic frontier

JN Fullerton, DW Gilroy - Nature reviews Drug discovery, 2016 - nature.com
JN Fullerton, DW Gilroy
Nature reviews Drug discovery, 2016nature.com
Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory
limbs of inflammation, with mixed success. However, insight into the pathways by which
inflammation is resolved has highlighted novel opportunities to pharmacologically
manipulate these processes—a strategy that might represent a complementary (and
perhaps even superior) therapeutic approach. This Review discusses the state of the art in …
Abstract
Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes — a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field.
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