Efficacy and safety of N-acetylcysteine in prevention of noise induced hearing loss: a randomized clinical trial

R Kopke, MD Slade, R Jackson, T Hammill, S Fausti… - Hearing research, 2015 - Elsevier
Despite a robust hearing conservation program, military personnel continue to be at high
risk for noise induced hearing loss (NIHL). For more than a decade, a number of laboratories
have investigated the use of antioxidants as a safe and effective adjunct to hearing
conservation programs. Of the antioxidants that have been investigated, N-acetylcysteine
(NAC) has consistently reduced permanent NIHL in the laboratory, but its clinical efficacy is
still controversial. This study provides a prospective, randomized, double-blinded, placebo …