Impaired unfolded protein response in the degeneration of cochlea cells in a mouse model of age-related hearing loss
W Wang, Y Sun, S Chen, X Zhou, X Wu, W Kong… - Experimental …, 2015 - Elsevier
Endoplasmic reticulum (ER) stress triggers the unfolded protein response (UPR) to prevent
the accumulation of proteins in an aberrant conformation. The UPR can restore homeostasis
by upregulating ER chaperones, such as glucose-regulated protein 78 kD (GRP78), to refold
the incorrectly handled protein, and by degrading the misfolded proteins via the ubiquitin–
proteasome and autophagy–lysosome system. ER stress was recently demonstrated to be
involved in the pathogenesis of age-related diseases. In this study, we measured the …
the accumulation of proteins in an aberrant conformation. The UPR can restore homeostasis
by upregulating ER chaperones, such as glucose-regulated protein 78 kD (GRP78), to refold
the incorrectly handled protein, and by degrading the misfolded proteins via the ubiquitin–
proteasome and autophagy–lysosome system. ER stress was recently demonstrated to be
involved in the pathogenesis of age-related diseases. In this study, we measured the …