Ebselen attenuates cochlear damage caused by acoustic trauma
A Pourbakht, T Yamasoba - Hearing research, 2003 - Elsevier
Ebselen (2-phenyl-1, 2-benzisoselenazol-3 (2H)-one), a seleno-organic compound, mimics
glutathione peroxidase and reacts with peroxynitrite. It is reported to protect against
gentamicin-and cisplatin-induced ototoxicity. We investigated whether it protects the cochlea
from acoustic trauma. Male pigmented guinea pigs (250–300 g) with normal auditory
brainstem response (ABR) thresholds were exposed for 5 h to 125 dB sound pressure level
octave band noise centered at 4 kHz. One hour before and 18 h after exposure, they …
glutathione peroxidase and reacts with peroxynitrite. It is reported to protect against
gentamicin-and cisplatin-induced ototoxicity. We investigated whether it protects the cochlea
from acoustic trauma. Male pigmented guinea pigs (250–300 g) with normal auditory
brainstem response (ABR) thresholds were exposed for 5 h to 125 dB sound pressure level
octave band noise centered at 4 kHz. One hour before and 18 h after exposure, they …