Cytokine and chemokine dysregulation in hyper-IgE syndrome
J Chehimi, M Elder, J Greene, L Noroski, ER Stiehm… - Clinical …, 2001 - Elsevier
Hyper-IgE syndrome is characterized by severe recurrent staphylococcal infections, eczema,
boney abnormalities, and markedly elevated levels of immunoglobulin E (IgE). The genetic
basis is not known and the central immunologic defect is largely undefined. Reduced
neutrophil chemotaxis is often described, and variable T cell defects have been
demonstrated in some patients. It has been hypothesized that hyper-IgE is associated with a
Th1/Th2 imbalance. We wished to characterize cytokine and chemokine imbalances that …
boney abnormalities, and markedly elevated levels of immunoglobulin E (IgE). The genetic
basis is not known and the central immunologic defect is largely undefined. Reduced
neutrophil chemotaxis is often described, and variable T cell defects have been
demonstrated in some patients. It has been hypothesized that hyper-IgE is associated with a
Th1/Th2 imbalance. We wished to characterize cytokine and chemokine imbalances that …