Attenuated atherogenesis in apolipoprotein E-deficient mice lacking amyloid precursor protein
TJL Van De Parre, PJDF Guns, P Fransen, W Martinet… - Atherosclerosis, 2011 - Elsevier
OBJECTIVE: Recent evidence suggests that amyloid precursor protein (APP) is
overexpressed in atherosclerosis-prone regions of mouse aorta. We therefore investigated
in the present study whether APP has a role in the progression and composition of
atherosclerotic plaques. METHODS AND RESULTS: Apolipoprotein E-deficient (apoE−/−)
mice were crossbred with animals lacking APP (APP−/−). After 16 weeks on a Western-type
diet, apoE−/− and APP−/−/apoE−/− mice showed similar cholesterol levels. However …
overexpressed in atherosclerosis-prone regions of mouse aorta. We therefore investigated
in the present study whether APP has a role in the progression and composition of
atherosclerotic plaques. METHODS AND RESULTS: Apolipoprotein E-deficient (apoE−/−)
mice were crossbred with animals lacking APP (APP−/−). After 16 weeks on a Western-type
diet, apoE−/− and APP−/−/apoE−/− mice showed similar cholesterol levels. However …
