Say no to et
PM Vanhoutte - Journal of the autonomic nervous system, 2000 - Elsevier
The endothelial cells relase both relaxing [nitric oxide (NO), endothelium-derived
hyperpolarizing factor (EDHF), prostacyclin] and contracting factors [endoperoxides,
thromboxane A2, superoxide anions, endothelin-1 (ET)]. The production of ET is inhibited by
NO. The latter also strongly opposes the direct effects of the former on vascular smooth
muscle. With aging and vascular disease, the production of enothelial NO declines, and thus
ET can be released, act and contribute to the symptoms.
hyperpolarizing factor (EDHF), prostacyclin] and contracting factors [endoperoxides,
thromboxane A2, superoxide anions, endothelin-1 (ET)]. The production of ET is inhibited by
NO. The latter also strongly opposes the direct effects of the former on vascular smooth
muscle. With aging and vascular disease, the production of enothelial NO declines, and thus
ET can be released, act and contribute to the symptoms.
