[HTML][HTML] Direct regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins
LA New, AK Chahi, N Jones - Journal of Biological Chemistry, 2013 - ASBMB
The transmembrane protein nephrin is a key component of the kidney slit diaphragm that
contributes to the morphology of podocyte foot processes through signaling to the
underlying actin cytoskeleton. We have recently reported that tyrosine phosphorylation of the
cytoplasmic tail of nephrin facilitates recruitment of Nck SH2/SH3 adaptor proteins and
subsequent actin remodeling and that phosphorylation of the Nck binding sites on nephrin is
decreased during podocyte injury. We now demonstrate that Nck directly modulates nephrin …
contributes to the morphology of podocyte foot processes through signaling to the
underlying actin cytoskeleton. We have recently reported that tyrosine phosphorylation of the
cytoplasmic tail of nephrin facilitates recruitment of Nck SH2/SH3 adaptor proteins and
subsequent actin remodeling and that phosphorylation of the Nck binding sites on nephrin is
decreased during podocyte injury. We now demonstrate that Nck directly modulates nephrin …
