Ototoxicity from cis-platinum in patients with stages III and IV previously untreated squamous cell cancer of the head and neck
S Fleming, V Ratanatharathorn, A Weaver… - American journal of …, 1985 - journals.lww.com
Abstract FORTY-FOUR PATIENTS WERE EVALUATED FOR OTOTOXICITY following
treatment with the chemotherapeutic agent cis-platinum. Statistically significant hearing
changes at 2,000 Hz (p< 0.001); 4,000 Hz (p< 0.05); and 8,000 Hz (p< 0.001) were
observed. Chi-square analysis demonstrated that at 8,000 Hz patients who had lower than
average thresholds prior to chemotherapy were more likely to experience greater threshold
shift than those patients whose pre-chemotherapy thresholds were higher than average. In …
treatment with the chemotherapeutic agent cis-platinum. Statistically significant hearing
changes at 2,000 Hz (p< 0.001); 4,000 Hz (p< 0.05); and 8,000 Hz (p< 0.001) were
observed. Chi-square analysis demonstrated that at 8,000 Hz patients who had lower than
average thresholds prior to chemotherapy were more likely to experience greater threshold
shift than those patients whose pre-chemotherapy thresholds were higher than average. In …